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| equilibrative nucleoside transporter 1 ： ウィキペディア英語版 |
equilibrative nucleoside transporter 1
Equilibrative nucleoside transporter 1 (ENT1) is a protein that in humans is encoded by the ''SLC29A1'' gene. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.〔
== Function ==
This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylmercaptopurine ribonucleoside (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack ''de novo'' nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2030 )〕
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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